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Définition :
La chélation du fer consiste à utiliser un agent qui fixe le fer présent dans les tissus et favorise son excrétion dans les urines et/ou les fèces.
Son objectif :
L’objectif du traitement chélateur du fer est d’éliminer la quantité de fer administrée lors des transfusions sanguines et de réduire la surcharge en fer déjà constituée.
De nombreux patients nécessitent des transfusions tout au long de leur vie. À ce jour, la déféroxamine est le seul traitement de première intention de la surcharge en fer post-transfusionnelle disponible dans le monde. Bien que la déféroxamine soit efficace, les contraintes liées à son mode d’administration limitent l’adhésion des patients au traitement qui, de ce fait, s’exposent aux risques associés à la surcharge en fer.
Hors ligne
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