Vous n'êtes pas identifié.
Molécule(s)
Dacarbazine
Classe thérapeutique
Cytotoxique antinéoplasique (agent alkylant)
Laboratoire(s)
Sanofi Aventis
Indications
DETICENE est utilisé dans les traitements des cancers suivants :
- sarcome des tissus mous de l'adulte (en association) ;
- mélanome malin (seul);
- lymphome hodgkinien de l'adulte (en association) ;
- lymphome non hodgkinien de l'adulte (en association).
Informations pratiques
DETICENE est délivré uniquement sur ordonnance.
Sa prescription et son renouvellement sont hospitaliers et réservés aux spécialistes en oncologie ou en hématologie ou aux médecins compétents en cancérologie.
DETICENE nécessite une surveillance particulière pendant le traitement, il se présente sous forme injectable.
Mode d'action
DETICENE empêche le développement et induit sélectivement la mort des cellules cancéreuses en s'attaquant à leur ADN.
En cas d'oubli
Contactez votre oncologue.
Effets secondaires
DETICENE provoque souvent immédiatement à l'injection un syndrome pseudogrippal avec fatigue, myalgies, malaises et fièvre. Il peut également provoquer des nausées, des vomissements, une aménorrhée (absence de règles) ou une azoospermie (pas de production de spermatozoïdes), une alopécie (perte de cheveux) modérée, des troubles de la formule sanguine.
N'hésitez pas à signaler tout effet secondaire à votre médecin.
Contre-indications / Précautions d'emploi
DETICENE est contre-indiqué en cas d'allergie à l'un des constituants, en cas de grossesse et d'allaitement, et en association avec le vaccin contre la fièvre jaune.
En raison d'une importante toxicité hématologique, une numération et une formule sanguine doivent être effectuées avant chaque prise et d'une façon générale, une surveillance hématologique stricte doit être maintenue.
Interactions médicamenteuses
Une surveillance accrue doit être mise en place en cas d'association avec les anticoagulants oraux.
DETICENE est formellement contre-indiqué en association avec le vaccin contre la fièvre jaune et la phénytoïne.
De plus il est déconseillé de l'associer avec les vaccins vivants atténués, et un traitement antérieur de phénytoïne même terminé.
Associé à la ciclosporine ou au tacrolimus, DETICENE peut provoquer une immunodépression (baisse des défenses immunitaires).
Ne pas associer le même jour à la fotémustine.
Surdosage
Les signes du surdosage ne peuvent être distingués des effets secondaires, si vous avez le moindre doute, faites le 15 ou contactez votre médecin rapidement.
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