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#1 15-12-2007 11:59:19

julien
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Depocyte

Molécule(s)    
Cytarabine


Classe thérapeutique    
Cytotoxique antimétabolite


Laboratoire(s)    
Mundipharma


Indications    
DEPOCYTE est utilisé dans le traitement de la méningite lymphomateuse, il est aussi utilisé en traitement palliatif de cette maladie.


Informations pratiques    
Délivré seulement sur ordonnance.

DEPOCYTE est délivré uniquement à l'hôpital, la prescription est réservée aux spécialistes en oncologie ou en hématologie ou aux médecins compétents en cancérologie.

DEPOCYTE nécessite une surveillance particulière pendant le traitement, il est injecté dans le liquide céphalo rachidien.

La formulation de DEPOCYTE repose sur une technologie innovante : celle-ci permet de diminuer la fréquence d'administration, en limitant les injections de DEPOCYTE à une toutes les deux semaines dans la phase d'induction, au lieu de deux ou trois par semaine avec la cytarabine classique.


Mode d'action    
Inhibe sélectivement la synthèse de l'ADN et donc la multiplication cellulaire.


Effets secondaires    
On observe fréquemment des maux de têtes, des nausées, des vomissements, de la fièvre, une raideur de la nuque, des douleurs dans la nuque et dans le dos. Ce phénomène appelé arachnoïdite est fréquent. C'est un signe de neurotoxicité et il doit être traité pour éviter toute aggravation.

On note également des mouvements anormaux et rythmiques des yeux (nystagmus), une instabilité à la marche et une déséquilibre (ataxie), une confusion, des hallucinations, une somnolence, des troubles auditifs.


Contre-indications / Précautions d'emploi    
DEPOCYTE est contre-indiqué en cas d'allergie à l'un des constituants, en cas de méningite, en cas de grossesse ou d'allaitement.

En cas de traitement simultané avec d'autres anticancéreux ou par une radiothérapie, la toxicité nerveuse est augmentée.

DEPOCYTE modifie la formule sanguine.

DEPOCYTE est déconseillé chez l'enfant.

En raison du risque de toxicité pour le foetus, DEPOCYTE ne doit pas être utilisé chez la femme en âge de procréer sans vérification qu'elle n'est pas enceinte.

En raison du risque de toxicité pour les spermatozoïdes, il est recommandé aux hommes en âge de procréer et à leur partenaire d'utiliser une contraception.


Interactions médicamenteuses    
La voie d'administration étant rare, il n'y a pas d'interactions référencées pour DEPOCYTE.


Surdosage    
L'administration hospitalière de DEPOCYTE permet de réduire largement les risques de surdosage, néanmoins une toxicité existe et la surveillance hospitalière est nécessaire pendant toute la durée du traitement.

 

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#12 20-05-2010 02:36:36

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