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#1 12-12-2007 10:21:44

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Daunoxome

Molécule(s)     
Daunorubicine


Classe thérapeutique    
Antibiotique cytotoxique


Laboratoire(s)    
Gilead Sciences


Indications    
DAUNOXOME est indiqué dans le traitement du sarcome de Kaposi cutanéo muqueux extensif ou viscéral, chez des patients à un stade avancé de l'infection par le VIH (virus de l'immunodéficience humaine).


Informations pratiques    
DAUNOXOME est disponible uniquement sur ordonnance.

DAUNOXOME doit être initialement prescrit à l'hôpital par des spécialistes en oncologie, les renouvellements peuvent ensuite être effectués par d'autres médecins.

DAUNOXOME se présente sous forme injectable, il s'agit d'une dispersion lisosomale.


Mode d'action    
Le principe actif de DAUNOXOME est un antibiotique antinéoplasique cytotoxique, il agit comme un agent alkylant c'est à dire qu'il modifie la structure de l'ADN et empêche la multiplication des cellules.


En cas d'oubli    
Consultez votre médecin.


Effets secondaires    
DAUNOXOME peut provoquer des maux de tête, des frissons, des vertiges, des douleurs dorsales, des flushs et une oppression thoracique au moment de la perfusion.

On note également des nausées, des vomissements, une ulcération des muqueuses, une insuffisance cardiaque, des arythmies, des bouffées de chaleur, une toxicité cardiaque, une perte de cheveux (alopécie), une nécrose locale (point d'injection), une myélosuppression (altération des cellules qui fabriquent les lignées sanguines), des réactions allergiques, des leucémies aigües.

DAUNOXOME peut colorer les urines en rouge.


DAUNOXOME a une forte toxicité cardiaque et une surveillance doit être effectuée durant le traitement.

DAUNOXOME peut également provoquer une toxicité hématologique (formule sanguine affectée).


Contre-indications / Précautions d'emploi    
DAUNOXOME est contre-indiqué en cas d'allergie à l'un de ses composants, de grossesse, d'allaitement.

L'association de DAUNOXOME avec d'autres chimiothérapies anticancéreuses induisant une myélosuppression est contre-indiquée.

Il est également contre-indiqué en association avec le vaccin contre la fièvre jaune, et la phénytoïne.

DAUNOXOME doit être utilisé avec prudence en cas d'atteinte cardiovasculaire, d'insuffisance cardiaque, de traitement antérieur par anthracycline, d'insuffisance médulaire, d'insuffisance hépatique.

Dans tous les cas, DAUNOXOME nécessite une surveillance particulière et de nombreux examens réguliers et si vous avez le moindre doute parlez en à votre médecin ou à l'équipe soignante.


Interactions médicamenteuses    
DAUNOXOME est formellement contre-indiqué en association avec le vaccin contre la fièvre jaune et la phénytoïne.

De plus il est déconseillé de l'associer avec les vaccins vivants atténués, et un traitement antérieur de phénytoïne même terminé.

Une surveillance particulière doit être effectuée en cas d'association avec les anticoagulants.

Associé à la ciclosporine ou au tacrolimus, DAUNOXOME peut provoquer une immunodépression (baisse des défenses immunitaires).


Surdosage    
DAUNOXOME est toxique est nécessite une surveillance particulière, si vous avez le moindre doute, faites rapidement le 15.

 

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