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Molécule(s)
Doxorubicine
Classe thérapeutique
Antinéoplasique cytotoxique (inhibiteur de la topoisomérase II)
Laboratoire(s)
Schering Plough
Indications
CAELYX est indiqué dans les traitements :
- du cancer du sein métastatique, avec un risqe cardiaque augmenté ;
- du cancer des ovaires à un stade avancé chez les femmes après l'échec d'une chimiothérapie de première intention à base de platine ;
- des sarcomes de Kaposi associé au SIDA.
Informations pratiques
CAELYX est délivré seulement sur ordonnance.
CAELYX est délivré uniquement à l'hôpital, la prescription est réservée aux spécialistes en oncologie ou en hématologie ou aux médecins compétents en cancérologie.
CAELYX nécessite une surveillance particulière pendant le traitement, il est donné sous forme injectable par voie intraveineuse lente uniquement (perfusion).
CAELYX est une forme liposomale, c'est à dire que le principe actif est encapsulé dans des liposomes, ce qui lui permet d'être plus actif et de limiter certains effets secondaires.
Mode d'action
Le principe actif de CAELYX inhibe la synthèse de l'ADN et de l'ARN en s'intercalant dans sa structure donc la multiplication cellulaire. Il fait partie de la famille des anthracyclines.
En cas d'oubli
Contactez votre oncologue.
Effets secondaires
L'effet secondaire principalement retrouvé est l’EPP (érythrodysesthésie palmoplantaire) qui est caractérisée par une éruption
cutanée douloureuse qui apparaît généralement après deux ou trois cycles
de traitement.
CAELYX provoque également des nausées, des vomissements, , des mucites, des stomatites, des pharyngites, une perte d’appétit, des paresthésies, une somnolence, des douleurs abdominales, une constipation, une diarrhée, des troubles digestifs, une ulcération de la bouche, un dessèchement de la peau, des irritations et démangeaisons, une pigmentation anormale, des crampes musculaires, des douleurs osseuses et musculaires, des douleurs mammaires, des saignements de nez, une fatigue, des malaises, un faiblesse, une asthénie (fatigue extrème), de la fièvre, des oedèmes notamment des membres inférieurs, des infections, des réactions allergiques, une déshydratation, une cachexie (état d’amaigrissement extrême), de l’anxiété, une dépression, des maux de tête, des étourdissements , des conjonctivites, une dyspnée (difficulté à respirer), et une augmentation de la toux.
La formule sanguine peut également être perturbée (neutropénie, leucopénie, anémie, thrombocytopénie).
CAELYX provoque une perte des cheveux importante (alopécie) elle est réversible à l’arrêt du traitement.
Contre-indications / Précautions d'emploi
CAELYX est contre-indiqué en cas d'allergie à l'un de ses composants, en cas de grossesse, et d'allaitement. De plus, les femmes dont le partenaire est traité par CAELYX doivent éviter une grossesse dans les six mois suivant la fin du traitement.
CAELYX ne doit pas être utilisé pour traiter le sarcome de Kaposi associé au SIDA qui pourrait être traité efficacement par un traitement local ou général avec l'interféron alpha.
CAELYX nécessite des précations d'emploi et une surveillance accrure chez les personnes atteintes d'une cardiopathie avec insuffisance myocardique, d'antécédents d'infarctus du myocarde, d'atteinte cardiovasculaire.
Dans tous les cas, une surveillance cardiaque et hématologique est nécessaire durant le traitement. Une numération, une formule sanguine et un électrocardiagramme seront réalisés avant chaque injection.
La surveillance doit être accrue en cas d'insuffisance hépatique, et de radiothérapie.
CAELYX n'a pas été évalué chez l'enfant (moins de 18 ans).
CAELYX contient du saccharose, en tenir compte en cas de diabète.
Interactions médicamenteuses
Les interactions médicamenteuses de CAELYX n'ont pas été évaluées, on prend néanmoins en compte celles de la doxorubicine sous forme conventiionnelle :
CAELYX ne doit pas être administré avec le cyclophosphamide car cela augmente les effets cardiotoxiques de la doxorubicine et le risque de cystite hémorragique du au cyclophosphamide. Il ne doit pas non plus être administré avec la mercaptopurine car cela augmente la toxicité hépatique (foie) provoquée par la mercaptopurine.
Il est également préférable de ne pas associer la doxorubicine à la ciclosporine et aux vaccins vivants atténués. Préférez un vaccin inactivé s'il existe.
Surdosage
Si vous avez le moindre doute, faites le 15.
Hors ligne
je cherche à savoir comment me procurer des brassards réfrigérants pour prévenir les effets secondaires liés au caelyx au niveau des mains et des pieds.
quel labo?
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