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#1 12-12-2007 09:10:24

destivic
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Lieu: Nantes
Date d'inscription: 30-11-2006
Messages: 140
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Amsalyo

Molécule(s)     
Amsacrine


Classe thérapeutique
Antinéoplasique cytotoxique (inhibiteur de la topoisomérase II)


Laboratoire(s)    
OTL Pharma



Indications    
AMSALYO est indiqué dans les traitements des leucémies aiguës lymphoblastiques et des leucémies aiguës myéloblastiques en cas de rechute ou d'échec des traitements conventionnels.


Informations pratiques    
AMSALYO est délivré seulement sur ordonnance.

AMSALYO est délivré uniquement à l'hôpital, la prescription est réservée aux spécialistes en oncologie ou en hématologie ou aux médecins compétents en cancérologie.

AMSALYO nécessite une surveillance particulière pendant le traitement, il est donné sous forme injectable par voie intraveineuse lente (perfusion) uniquement.


Mode d'action    
Le principe actif de AMSALYO inhibe la synthèse de l'ADN de façon sélective en s'intercalant dans sa structure et donc inhibe la multiplication cellulaire.


En cas d'oubli    
Contactez votre oncologue.


Effets secondaires    
AMSALYO provoque fréquemment des troubles digestifs tels que des nausées, des vomissements, une diarrhée, mais également des stomatites, des effets locaux au point d'injection (brûlures, thrombose veineuse...), une alopécie (perte de cheveux), une myélosuppression (la moelle osseuse ne remplit plus sa fonction et ne fabrique les cellules de défenses immunitaires et les cellules sanguines) qui entraîne des infections et des hémorragies.


Contre-indications / Précautions d'emploi    
AMSALYO est contre-indiqué en cas d'allergie à l'un de ses composants, en cas de grossesse, d'allaitement, d'aplasie médullaire.

Dans tous les cas, une surveillance médicale stricte hépatique, rénale et hématologique est nécessaire durant le traitement.

La surveillance cardiaque doit être accrue en cas de traitement antérieur par une anthracycline.

La posologie sera adaptée en cas d'insuffisance rénale ou hépatique chronique.


Interactions médicamenteuses    
La dose de AMSALYO doit être adaptée en cas d'association avec la cytosine arabinoside ou l'azacytidine afin de diminuer la toxicité digestive.


Surdosage    
AMSALYO est toxique, si vous avez le moindre doute, faites rapidement le 15.


_________________________
*************************
L'avenir est une solution...   wink

Hors ligne

 

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